沈庆汤 副研究员
硕士生导师
联系邮箱：qt[email protected]
个人简介
沈庆汤，男，副研究员，硕士生导师。浙江大学博士，法国巴黎七大/法国国家健康与医学研究院（insermU944），和多伦多大学医学院博士后。福建省引进高层次人才（境外C类）、福建省级高层次人才（C类）、熟女a片 第四层次引进人才；福建省免疫学会理事。
研究领域
1.病毒感染与抗病毒固有免疫；
2.儿童急性坏死性脑病（ANE1）的致病机理。
主持/参与的项目
近5年主持的项目：
1. 福建省自然科学基金面上项目，病毒感染与固有免疫互作分子机制方向，10万，2024.11-2027.11，主持。
2. 福建省科技创新联合资金项目，固有免疫和ANE1致病机制方向，15万，2021.8-2024.8，主持。
3. 福建省自然科学基金面上项目，病毒感染与固有免疫互作分子机制方向，7万，2020.11-2023.11，主持。
4. 熟女a片 高层次人才启动基金，固有免疫和ANE1致病机制方向，100万，2019.7-2024.7，主持。
曾主持项目：
1.中国博士后科学基金项目，3万，项目编号2011M501015，2011.9-2012.10，主持。
2. 国家自然科学基金青年项目，26万，项目编号31200205，2013.01-2015.12，主持。
科研成果
1. Jiawei Li#, Lili Su#, Jing Jiang, Yifan E. Wang, Yingying Ling, Yi Qiu, Huahui Yu, Yucong Huang, Jiangmin Wu, Shan Jiang, Tao Zhang, Alexander F. Palazzo* and Qingtang Shen*. 2024. RanBP2/Nup358 Mediates Sumoylation of STAT1 and Antagonizes Interferon-α-Mediated Antiviral Innate Immunity. Int. J. Mol. Sci. 25(1):299. (SCI-JCR 1区，中科院二区；IF=5.6；最后通讯作者)
2. Vanessa W Lee, Kai Qian Kam, Ahmad R Mohamed, Husna Musa, Poorani Anandakrishnan, Qingtang Shen, Alexander F Palazzo, Russell C Dale, Ming Lim, Terrence Thomas. 2024. Defining the Clinicoradiologic Syndrome of SARS-CoV-2 Acute Necrotizing Encephalopathy: A Systematic Review and 3 New Pediatric Cases. Neurol Neuroimmunol Neuroinflamm. 11(1):e200186. (SCI-JCR 1区，中科院一区；IF=7.8)
3. Pan Gong#, Qingtang Shen#, Mingzhen Zhang#, Rui Qiao, Jing Jiang, Lili Su, Siwen Zhao, Shuai Fu, Yu Ma, Linhao Ge, Yaqin Wang, Rosa Lozano-Durán, Aiming Wang, Fangfang Li*, Xueping Zhou*. 2023. Plant and animal positive-sense single-stranded RNA viruses encode small proteins important for viral infection in their negative-sense strand. Mol Plant S1674-2052(23)00291-5. (SCI-JCR 1区，中科院一区；IF=27.5； #共同第一作者)
4. Jing Jiang#,Yifan E. Wang#, Alexander F. Palazzo*, Qingtang Shen*. 2022. Roles of Nucleoporin RanBP2/Nup358 in Acute Necrotizing Encephalopathy Type 1 (ANE1) and Viral Infection. Int. J. Mol. Sci. 23(7):3548 (SCI-JCR 1区，中科院二区TOP；IF=6.2；最后通讯作者)
5. Qingtang Shen#*, YiFan E. Wang#, Alexander F. Palazzo*. 2021. Crosstalk between nucleocytoplasmic trafficking and the innate immune response to viral infection. J Biol Chem 297(1):100856 (Nature index期刊；SCI-JCR 2区，中科院二区TOP；IF=5.5；共同第一兼共同通讯作者)
6. Qingtang Shen#*, YiFan E. Wang#, Mathew Truong, Kohila Mahadevan, Jing Ze J Wu, Hui Zhang, Jiawei Li, Harrison W. Smith, Craig Smibert, Alexander F. Palazzo*. 2021. RanBP2/Nup358 enhances miRNA activity by sumoylating Argonautes. PLoS Genet 17(2): e1009378 (Nature index期刊；SCI-JCR 1区，中科院二区TOP；IF=6.0；共同第一兼共同通讯作者)
7. Ting-Hin Ho, Justine Sitz, Qingtang Shen, Ariane Leblanc-Lacroix, Eric I. Campos, Ivan Borozan, Edyta Marcon, Jack Greenblatt, Amelie Fradet-Turcotte, Dong-Yan Jin and Lori Frappier*. 2018. A Screen for Epstein-Barr Virus Proteins that Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein. JVirol. doi:10.1128/JVI.00262-18 (IF=6.5)
8. Qingtang Shen, Nissrine Beyrouthy, Laura Matabishi-Bibi and Catherine Dargemont*. 2017. The chromatin remodeling Isw1a complex is regulated by SUMOylation. Biochem J 474(20): 3455-3469 (IF=3.8)
9. Anna Babour*, Qingtang Shen, Julien Dos-Santos, Struan Murray, Alexandre Gay, Drice Challal, Milo Fasken, Benoît Palancade, Anita Corbett, Domenico Libri, Jane Mellor and Catherine Dargemont. 2016. The chromatin remodeler ISW1 is a quality control factor that surveys nuclear mRNP Biogenesis. Cell 167, 1201–1214 (IF=66.9)
10. Qingtang Shen, Tao Hu, Min Bao, Linge Cao, Huawei Zhang, Fengmin Song, Qi Xie, Xueping Zhou*. 2016. Tobacco RING E3 ligase NtRFP1 mediates ubiquitination and proteasomal degradation of a geminivirus-encoded betaC1. Mol Plant 9(6): 911-925 (IF=21.9)
11. Yajuan Qian, Huwei Hou, Qingtang Shen, Xinzhong Cai, Garry Sunter, Xueping Zhou*. 2016. RepA Protein Encoded by Oat dwarf virus Elicits a Temperature-Sensitive Hypersensitive Response-Type Cell Death That Involves Jasmonic Acid-Dependent Signaling. Mol Plant Microbe Interact 29(1):5-21 (IF=3.4)
12. Qingtang Shen, Min Bao, Xueping Zhou*. 2012. A plant kinase plays roles in defense response against geminivirus by phosphorylation of a viral pathogenesis protein. Plant Signal Behav 7(7): 887 – 891 (IF=2.7)
13. Qingtang Shen#, Zhou Liu#, Fengming Song, Qi Xie, Linda Hanley-Bowdoin, Xueping Zhou*. 2011. Tomato SlSnRK1 protein interacts with and phosphorylates betaC1, a pathogenesis protein encoded by a geminivirus beta-satellite. Plant Physiol 157(3): 1394-1406 (IF=8.0，#共同第一作者)
14. Xiuling Yang, Yan Xie, Priya Raja, Sizhun Li, Jamie N. Wolf, Qingtang Shen, David M. Bisaro, Xueping Zhou*. 2011. Suppression of methylation-mediated transcriptional gene silencing by betaC1-SAHH protein interaction during geminivirus-betasatellite infection. PLoS Pathog 7(10):e1002329 (IF=7.5)
指导学生
1.已毕业学生：硕士：李佳蔚、姜荆（校优秀毕业生）、苏莉莉、黄宇聪（校优秀毕业生）；学士：胡嘉昙、令颖颖（校优秀毕业生）、江山、阿依努尔•麦麦提、古丽娜孜亚•阿不来克；
2.在读研究生：王雅洁、肖清婷、陈艺、AMJITH KHAN、Mohammed A.Diallo；
3.在读本科生：汪鑫、饶泰鹏、陈心桐、李祖民。
4.指导研究生获福建省基础医学研究生创新大赛学术墙报省级三等奖1项；指导本科生获“国家级大学生创新训练项目”两项。
(更新至2025年7月)
