张莉  副教授

硕士生导师

联系邮箱：[email protected]

个人简介

张莉，女，副教授，硕士生导师。哈尔滨医科大学药理学专业获医学博士学位。加拿大卡尔加里大学访问学者。获福建省高层次人才B类、担任中国生理学会循环生理专业委员会委员，中国病理生理学会动脉粥样硬化专业委员会青年委员，国际动脉粥样硬化协会中国分会理事，福建省心血管药理科学会委员，福建省生理科学会理事，《中国动脉硬化杂志》编委，教育部学术论文评审专家。

研究领域

1.主动脉瘤/夹层

2.肺动脉高压

主持/参与的项目

1.福建省自然科学基金项目(面上)，Tex261调节肺血管平滑肌细胞增殖在肺动脉高压中的作用研究，10万，主持

2.国家自然科学基金，糖脂代谢异常在主动脉夹层发生中的作用（联合申请B），200万，主要参与人

3.福建省科技创新联合资金项目计划，K1调控细胞稳态介导肺血管重构的机制研究，50万，主持

4.福建省卫生计生科研中青年骨干人才培养项目，Galectin-3在缺氧肺动脉高压外膜滋养血管新生中的作用，10万，主持

5.福建省自然科学基金，Galectin-3调节肺血管外膜滋养血管新生的网络机制，10万，主持

6.人才启动金，外泌体galectin-3介导内皮细胞在缺氧肺血管外膜滋养血管新生中的作用，100万，主持

7.国家自然科学基金青年基金，15-LO/15-HETE在缺氧性肺动脉高压血管外膜重构中的作用及机制研究，23万，主持

8.中国博士后特别资助，15-LO与TGF-β1交互效应在血管外膜重构中的作用机制，15万，主持

9.福建省普通本科高等学校青年创新人才培养计划，HSPB1与细胞膜F1F0-ATPase交互效应在肺动脉高压肺血管滋养血管重构中的作用，10万，主持

10.中国博士后面上资助，15-LO与TGF-β1交互效应在血管外膜重构中的作用机制，5万，主持

科研成果

1. Jiakang Li, Zhihuang Qiu, Rumei Xie, Likang Ma, Lele Tang, Mengge Yao, Zhaofeng Zhang, Liangwan Chen, Li Zhang. CXCL2 mediates lactate secretion and promotes aortic dissection formation through the p38/JNK/C-myc pathways. Thrombosis and Haemostasis. doi.org/10.1055/a-2600-6318

2. Pan Wang, Xu Zhang, Mengge Yao, Jiakang Li, Xiaozhen Wei, Zhihuang Qiu, Liangwan Chen, Li Zhang. Targeting high mobility group protein B2 exerts antiproliferative effects in hypoxic pulmonary hypertension by modulating miR-21. Toxicol Appl Pharmacol. 2025:497:117265.

3. Ma L, Xie L, Wu Q, Jin L, Li J, Tang L, Zhang L*, Chen L*, Qiu Z*. Targeting the S100A9/P38 MAPK/HSPB1 axis as a novel approach for aortic dissection therapy. Int Immunopharmacol. 2025;149:114225.

4. Yameng Zheng, Mengge Yao, Shaokun Chen, Jiakang Li, Xiaozhen Wei, Zhihuang Qiu, Liangwan Chen, Li Zhang. HMGB2 promotes smooth muscle cell proliferation through PPAR-γ/PGC-1α pathway-mediated glucose changes in aortic dissection. Atherosclerosis. 2024:399:119044.

5. Li Zhang, Zhi-Huang Qiu, Xiaozhen Wei, Mengge Yao, Shao-Kun Chen, Jian He, Jian-Qiang Ye, Yu-Mei Li, Liang-Wan Chen. 10xsingle-cell sequencing revealed cellular composition heterogeneity in cardiac myxoma with malignant glandular properties. Microvasc Res. 2024 154:104697. 

6.谢如眉,李家康,姚萌格,张莉.（专家论坛）PRDX6在心血管疾病中的研究进展.中国动脉硬化杂志.2024,32(11),932-938.

7. Chaoyun Wang*, Li Zhang*, Qinghua Zhang, Hui Zheng, Xi Yang, Weixing Cai, Qiuying Zou, Jingjing Lin, Lin Zhang, Lin Zhong, Xinyao Li, Yuqing Liao, Qin Liu, Liangwan Chen, Yumei Li. Transketolase drives the development of aortic dissection by impairing mitochondrial bioenergetics. Acta Physiol (Oxf). 2024;240(4):e14113.

8. Shaokun Chen, Xiaozhen Wei, Xu Zhang, Mengge Yao, Zhihuang Qiu, Liangwan Chen, Li Zhang. Supplementation with Tex261 provides a possible preventive treatment for hypoxic pulmonary artery hypertension. Front Pharmacology.

9. Xinghe Chen, Xiaozhen Wei, Saijie Ma, Huating Xie, Sirui Huang, Mengge Yao, Li Zhang. Cysteine and glycine rich protein 2 exacerbates vascular fibrosis in pulmonary hypertension through the nuclear translocation of yes-associated protein and transcriptional coactivator with PDZ-binding motif. Toxicol Appl Pharmacol. 2022;457:116319.

10. Li Zhang, Zhihuang Qiu, Hui Zheng, Xi Yang, Jianqiang Ye, Jian He, Yumei Li, Liangwan Chen. Single Cell RNA Sequencing Reveals the Pathogenesis of Aortic Dissection Caused by Hypertension and Marfan Syndrome. Front Cell Dev Biol. 2022;10:880320.

11. Liyu Tang, Nan Wang, Xiaozhen Wei, Sirui Huang, Pan Wang, Yameng Zheng, Liangwan Chen, Li Zhang. Cysteine and glycine-rich protein 2 promotes hypoxic pulmonary vascular smooth muscle cell proliferation through the Wnt3α-β-catenin/lymphoid enhancer-binding factor 1 pathway. J Biochem Mol Toxicol. 2022;e23122.  

12. Li Zhang, Xi-Xi Zeng, Yu-Mei Li, Shao-Kun Chen, Li-Yu Tang, Nan Wang, Xi Yang, Mo-Jun Lin. Keratin 1 attenuates hypoxic pulmonary artery hypertension by suppressing pulmonary artery media smooth muscle expansion Acta Physiol (Oxf). 2021;231(2):e13558.

13. Yumei Li, Xinghe Chen, Xixi Zeng, Shaokun Chen,Xi Yang,Li Zhang. Galectin‐3 mediates pulmonary vascular endothelial cell dynamics via TRPC1/4 under acute hypoxia. J Biochem Mol Toxicol. 2020;34(5):e22463.

14. Zhang L, Chen S, Zeng X, Lin D, Li Y, Gui L, Lin MJ. Revealing the pathogenic changes of PAH based on multiomics characteristics. J Transl Med. 2019;17(1):231.

15. Li Zhang, Yu-mei Li, Xi-xi Zeng, Xiao-yan Wang, Shao-kun Chen, Long-xin Gui Mo-jun Lin. Galectin-3-Mediated Transdifferentiation of Pulmonary Artery Endothelial Cells Contributes to Hypoxic Pulmonary Vascular Remodeling. Cell Physiol Biochem 2018;51:763-777.

（更新于2025年7月）