朱安  副教授

硕士生导师，病原学系副主任

联系邮箱：[email protected]

个人简介

朱安，副教授，硕士生导师。2009-2017年于兰州大学获医学学士和硕士学位，2020年于北京大学获医学博士学位。Toxics、Frontiers in Genetics客座编辑，Epigenetics Insights青年编委，Phytomedicine等40余本SCI杂志审稿人。发表论文51篇，其中第一和通讯作者29篇。中华中医药学会中药毒理学与安全性研究分会委员、福建省生物工程学会副监事长、福建省高层次人才C类。中国毒理学会、中华中医药学会、中国环境诱变剂学会会员。

研究领域

1.天然产物药理毒理

2.真毒菌素毒性

主持的项目

1.国家自然科学基金青年项目，线粒体损伤在千金子甾醇致肠道毒性中的作用及机制研究

2.福建省自然科学基金青年创新项目，TGF-β1介导的CaMKKβ/AMPK信号通路在千金子甾醇致肠道紧密连接损伤中的作用及机制

3.福建省科技创新联合资金项目，基于AMPK/SIRT1/PGC-1α通路介导的能量代谢重编程研究千金子素L1诱发肠细胞自噬的毒性机制

科研成果

1.Yifan Lin, Jian Zhang, Xinyue Gao, Zekai Wu, Lele Yang, Kun Tian, Xiaoqi Lv, Jiaqi Li, Kunqi Chen, Youbo Zhang, Hong Hu, An Zhu. Toosendanin-induced liver damage through irreparable DNA damage and autophagy flow blockade. Phytomedicine. 2025, 140, 156586.

2.An Zhu, Xueqing Yan, Mengting Chen, Yifan Lin, Lanqian Li, Yufei Wang, Jiabin Huang, Jiale He, Mengchen Yang, Wenxi Hua, Kunqi Chen, Jing Qi, Zixiong Zhou. Sappanone A alleviates metabolic dysfunction-associated steatohepatitis by decreasing hepatocyte lipotoxicity via targeting Mup3 in mice. Phytomedicine. 2025,136, 156341.

3.Zekai Wu, Jian Zhang, Yajiao Wu, Mengting Chen, Hong Hu, Xinyue Gao, Chutao Li, Maodong Li, Youbo Zhang, Xiaohuang Lin, Qiaomei Yang, Li Chen, Kunqi Chen, Lifeng Zheng, An Zhu. Gelsenicine disrupted the intestinal barrier of Caenorhabditis elegans. Chemico-Biological Interactions. 2024, 395:111036.

4.Xiaoying Chen, Hong Hu, Xiaohuang Lin, Mengting Chen, Wenqiang Bao, Yajiao Wu, Chutao Li, Yadong Gao, Shaozhang Hou, Qiaomei Yang, Li Chen, Jian Zhang, Kunqi Chen, Qi Wang, An Zhu, Euphorbia factor L1 inhibited transport channel and energy metabolism in human colon adenocarcinoma cell line Caco-2. Biomedicine & Pharmacotherapy. 2023, 169, 115919.

5.An Zhu, Fuli Zheng, Wenjing Zhang, Ludi Li, Yingzi Li, Hong Hu, Yajiao Wu, Wenqiang Bao, Guojun Li, Qi Wang, Huangyuan Li. Oxidation and antioxidation of natural products in the model organism Caenorhabditis elegans. Antioxidants. 2022; 11(4):705.

（更新于2025年7月）