林小煌 副研究员
硕士生导师
联系邮箱：[email protected]
个人简介
林小煌，男，1993年5月生，遗传学博士，硕士生导师，福建省高层次C类人才。2015年毕业于福建农林大学生物科学专业，获理学学士学位，2020年毕业于中国科学院大学遗传学，获遗传学博士学位。2020年8月就职于熟女a片 。从事分子生物学教学与科研工作，发表SCI论文十余篇。
研究领域
1.肿瘤代谢及蛋白翻译后修饰
2.功能蛋白质组学
主持/参与的项目
1. 国家自然科学基金，青年科学基金项目，有氧糖酵解调控NPM1蛋白修饰引起肿瘤化疗耐药的机制研究，82203164，2023-01-01至2025-12-31，30万元，在研，主持。
2. 福建省科技厅, 福建省自然科学基金青年项目, 2021J05044, 乙型肝炎病毒引起RNA结合蛋白NONO赖氨 酸乳酸化的功能和机制研究, 2021-09 至 2024-11, 8万元, 结题, 主持；
3. 熟女a片 科技处，高层次人才科研启动项目，XRCZX2020013，HBV感染的肝癌细胞中赖氨酸乳酸化修饰的功能研究，2020-09-03至2025-09-01，20万元，在研，主持；
科研成果
(1) Gao, M., Liu, T., Hu, K., Chen, S., Wang, S., Gan, D., Li, Z., & Lin, X. (2024). Ribosomal Dysregulation in Metastatic Laryngeal Squamous Cell Carcinoma: Proteomic Insights and CX-5461's Therapeutic Promise. Toxics, 12(5), 363.
(2) Zhang, J., Gao, Z., Yang, Y., Li, Z., Wu, B., Fan, C., Zheng, Y., Yang, R., Zhang, F., Lin, X., & Zheng, D. (2024). SNF2L maintains glutathione homeostasis by initiating SLC7A11 transcription through chromatin remodeling. Cell death & disease, 15(11), 820.
(3) Lin, X., Zhang, J., Wu, Z., Shi, Y., Chen, M., Li, M., Hu, H., Tian, K., Lv, X., Li, C., Liu, Y., Gao, X., Yang, Q., Chen, K., & Zhu, A. (2024). Involvement of autophagy in mesaconitine-induced neurotoxicity in HT22 cells revealed through integrated transcriptomic, proteomic, and m6A epitranscriptomic profiling. Frontiers in pharmacology, 15, 1393717.
(4) Chen, M., Wen, J., Qiu, Y., Gao, X., Zhang, J., Lin, Y., Wu, Z., Lin, X., & Zhu, A. (2024). Combining Multiple Omics with Molecular Dynamics Reveals SCP2-Mediated Cytotoxicity Effects of Aflatoxin B1 in SW480 Cells. Toxins, 16(9), 375.
(5) Zhou Z, Qi J, Wu Y, Li C, Bao W, Lin X., Zhu A. Nuciferine Effectively Protects Mice against Acetaminophen-Induced Liver Injury. Antioxidants (Basel). 2023 Apr 18;12(4):949.
(6) Cao G, Lin X., Ling M, Lin J, Zhang Q, Jia K, Chen B, Wei W, Wang M, Jia S, Yang M, Ge F. cKMT1 is a New Lysine Methyltransferase That Methylates the Ferredoxin-NADP(+) Oxidoreductase and Regulates Energy Transfer in Cyanobacteria. Mol Cell Proteomics. 2023 Apr;22(4):100521.
(7) Chen, X., Hu, H., Lin, X., Chen, M., Bao, W., Wu, Y., Li, C., Gao, Y., Hou, S., Yang, Q., Chen, L., Zhang, J., Chen, K., Wang, Q., & Zhu, A. (2023). Euphorbia factor L1 inhibited transport channel and energy metabolism in human colon adenocarcinoma cell line Caco-2. Biomedicine & pharmacotherapy, 169, 115919.
(8) Lin, X., Yang, M., Liu, X., Cheng, Z., & Ge, F. (2020). Characterization of Lysine Monomethylome and Methyltransferase in Model Cyanobacterium Synechocystis sp. PCC 6803. Genomics, proteomics & bioinformatics, 18(3), 289–304.）
(10) Yang, M., Lin, X., Liu, X., Zhang, J., & Ge, F. (2018). Genome Annotation of a Model Diatom Phaeodactylum tricornutum Using an Integrated Proteogenomic Pipeline. Molecular plant, 11(10), 1292–1307.
(11) Liu X, Yang M, Wang Y, Chen Z, Zhang J, Lin X., Ge F, Zhao J. Effects of PSII Manganese-Stabilizing Protein Succinylation on Photosynthesis in the Model Cyanobacterium Synechococcus sp. PCC 7002. Plant Cell Physiol. 2018 Jul 1;59(7):1466-1482.
(12) Ma, Y., Yang, M., Lin, X., Liu, X., Huang, H., & Ge, F. (2017). Malonylome Analysis Reveals the Involvement of Lysine Malonylation in Metabolism and Photosynthesis in Cyanobacteria. Journal of proteome research, 16(5), 2030–2043.
（更新于2025年7月）
