李华 讲师
硕士生导师
联系邮箱：[email protected]
个人简介
李华，女，讲师，硕士生导师。福建师范大学发育生物学专业获博士学位。校第六层次引进人才。
研究领域
1.窦房结发育及其异常机制的研究
2.睾丸发育及其异常机制的研究
主持/参与的项目
1.福建省科技创新联合资金项目，“CCDC149调控睾丸下降的机制研究”，2024.12至2027.12，15万元/3年，在研，主持。
2.福建省自然科学基金（面上）,“采用单细胞转录组测序解构Nkx2-5+起搏细胞关键调控因子”，2021-11至2024-11，7万/3年，结题，主持。
3.熟女a片 启航基金，“解构Nkx2-5定义的起搏细胞”，2021-04至2024-04，5万/3年，在研，主持。
4.美国National Institute of Health (NIH)基金，“Genetic and transcription regulation of cardiac pacemaker fate”，2017-07至2021-06，25万美金/每年，结题，主要参与。
5.美国National Institute of Health (NIH)基金，“Molecular patterning of the hard palate during palatogenesis”，2017-04至2022-01，25万美金/每年，结题，主要参与。
6.国家自然科学基金，“病态窦房结综合征细胞与基因治疗技术的研究”，2013-10至2016-10，60万，结题，主要参与。
科研成果
1. Shengrong Du#, Shan Xu#, Lei Yang, Yan Ye, Yuhan Wu, Ziyun Xiao, Xiuqing Dong*, Wenliang Yao*, Hua Li#*. Cryptorchidism: Novel genetic insights into CCDC149 mutations. Andrology. 2025. //doi.org/10.1111/andr.70072. (IF:3.4，中科院1区)
2. Hua Li, Zejun Cai, Yue Liu,Yong Chen, Qiaomei Lin, Hui Liu*. The effect of PBL teaching method in the teaching of congenital malformation. Frontiers in medicine. 2025. //doi.org/10.3389/fmed.2025.1508415. (IF: 3.0，中科院分区3区)
3. Hua Li#*, Qinghuang Tang#, Tianfang Yang, Zhengsen Wang, Dainan Li, Linyan Wang, Liwen Li, Yaoyi Chen , Hai Huang , Yanding Zhang, YiPing Chen*. Segregation of morphogenetic regulatory function of Shox2 from its cell fate guardian role in sinoatrial node development. Communications Biology. 2024. //doi.org/10.1038/s42003-024-06039-2. (IF: 5.10，中科院1区)
4. Hua Li, Dainan Li, Yuzhi Wang, Zhen Huang, Jue Xu, Tianfang Yang, Linyan Wang, Qinghuang Tang, Chen-Leng Cai, Hai Huang, Yanding Zhang, YiPing Chen*. Nkx2-5 defines a subpopulation of pacemaker cells and is essential for the physiological function of the sinoatrial node in mice. Development. 2019: dev.178145. (IF: 6.862，中科院1区)
5. Jiandong Sun#, Hua Li#, Chengyu Lv#, Eman Draz, Yue Liu, Zihang Lin, Weitao Hu, Kaien Mo, Jianmin Lin, Weiwei Xu, Shie Wang*. Trps1 targets Ccnd1 to regulate mouse Leydig cell proliferation. Andrology. 2021. //doi.org/10.1111/andr.13072. (IF: 4.46，中科院分区1区)
6. Qinghuang Tang#*, Liwen Li#, Yihong Li, Amy Wang, Hua Li, Linyan Wang, Cong Gu, Jung-Mi Lee, Zhaoming Wu, Hyuk-Jae Edward Kwon*, YiPing Chen*. Distinct BMP-Smad signaling outputs confer diverse functions in dental mesenchyme. Development. 2025: dev.204563. (IF: 3.2，中科院2区)
7. Xi Zheng#, Fengjiao Wang#, Xiaoxiao Hu#, Hua Li, Zhen Guan, Yanding Zhang, Xuefeng Hu*. PDGFRα-Signaling Is Dispensable for the Development of the Sinoatrial Node After Its Fate Commitment. Front. Cell Dev. Biol. 2021. 9: 647165. (IF: 6.081，中科院2区)
8. Tianfang Yang#, Zhen Huang#, Hua Li, Linyan Wang, YiPing Chen*. Conjugated activation of myocardial-specific transcription of Gja5 by a pair of Nkx2-5-Shox2 co-responsive elements. Developmental Biology. 2020. 465(1): 79-87. (IF: 3.708，中科院3区)
9. Linyan Wang, Qinghuang Tang, Jue Xu, Hua Li, Tianfang Yang, Liwen Li, Ondrej Machon, Tao Hu, YiPing Chen*. The transcriptional regulator MEIS2 sets up the ground state for palatal osteogenesis in mice. Journal of Biological Chemistry. 2020: RA120.012684. (IF: 4.238，中科院2区)
10. Jue Xu, Linyan Wang, Hua Li, Tianfang Yang, Yanding Zhang, Tao Hu*, Zhen Huang* and YiPing Chen*. Short stature homeobox 2 (SHOX2) regulates osteogenic differentiation and pattern formation during hard palate development in mice. Journal of Biological Chemistry. 2019: RA119.008801. (IF: 4.238，中科院2区)
11. Yingnan Song, Bingmei Wang, Hua Li, Xiaoxiao Hu, Xin Lin, Xuefeng Hu, and Yanding Zhang*. Low temperature culture enhances ameloblastic differentiation of human keratinocyte stem cells. Journal of molecular histology. 2019. 50(5): 417-425. (IF: 2.309，中科院4区)
12. Jue Xu#, Zhen Huang#, Xiaoqian Tan, Weiqi Wang, Hua Li, Yanding Zhang, Weidong Tian, Tao Hu*, and Yiping Chen*. FGF8 signaling alters the osteogenic cell fate in the hard palate. Journal of Dental Research. 2018. 97(5):589-596. (IF: 5.125，中科院2区)
（更新于2025年7月）
