李锐 研究员
博士生导师
联系邮箱：lirui158@fjmu.edu.cn
个人简介
李锐，男，研究员，博士生导师，博士毕业于加拿大麦吉尔大学（McGill University），后在美国宾夕法尼亚大学（University of Pennsylvania）完成博士后的研究工作。2022年任宾夕法尼亚大学神经炎症与实验治疗中心科研主任。2023年全职回国加入熟女a片 神经科学研究院。
研究领域
1.调控B细胞亚群平衡的分子代谢机制
2.B细胞衰老与神经退行性疾病的关系
3.新一代B细胞靶向药物在神经系统炎性疾病中的应用
主持/参与的项目
1.国家自然科学基金优秀青年基金（海外），B细胞亚群在多发性硬化进展中的功能与机制（200万元），起止时间2023.1-2025.12，主持
2.国家自然科学基金区域创新发展联合基金重点项目，调节B细胞亚群平衡的分子代谢机制及其在治疗多发性硬化中的潜在应用（260万元），起止时间2024.1-2027.12，主持
3.国家自然科学基金面上项目，CD20dimCD8+T细胞在多发性硬化中的作用及机制研究（50万元），起止时间2024.1-2027.12，主持
4.省多中心临床研究项目，IDOT检测NMOSD相关抗体AQP4-IgG效能的前瞻性、多中心、开放标签、盲法评价的临床研究（150万元），起止时间2024.12-2027.12，主持
科研成果
1. Rui Li†,*, Yanting Lei, Ayman Rezk, Diego A. Espinoza, Jing Wang, Huiru Feng, Bo Zhang, Isabella P. Barcelos, Hang Zhang, Jing Yu, Xinrui Huo, Fangyi Zhu, Changxin Yang, Hao Tang, Amy C. Goldstein, Brenda L. Banwell, Hakon Hakonarson, Hongwei Xu, Michael Mingueneau, Bo Sun, Hulun Li, Amit Bar-Or*. Oxidative phosphorylation regulates B cell effector cytokines and promotes inflammation in multiple sclerosis. Science Immunology, 2024, 9(95): eadk0865. doi:10.1126/sciimmunol.adk0865.(IF: 24.8,中科院1区)
2. Diego A. Espinoza, Carole Le Coz, Emylette Cruz Cabrera, Neil Romberg, Amit Bar-Or*, Rui Li*. Distinct stage-specific transcriptional states of B cells derived from human tonsillar tissue. JCI-insight, 2023, 8(7):e155199.doi:10.1172/jci.insight.155199.(IF: 8,中科院1区)
3. Rui Li†, Hao Tang, Jeremy C. Burns, Brian T. Hopkins, Carole Le Coz, Bo Zhang, Isabella Barcelos, Neil Romberg, Amy C. Goldstein, Brenda L. Banwell, Eline T. Luning Prak, Michael Mingueneau, Amit Bar-Or*. BTK inhibition impacts with B cell - T cell interaction through modulation of B cell metabolism: implications for MS therapies. Acta Neuropathologica.2022.143(4):505-521. doi:10.1007/s00401-022-02411-w.(IF: 12.7,中科院1区)
4. Leah Zuroff, Ayman Rezk, Koji Shinoda, Diego Espinoza, Bo Zhang, Roy N Alcalay, Thomas Tropea, Alice Chen-Plotkin, Rui Li*, Amit Bar-Or*. Immune aging in multiple sclerosis is characterized by abnormal CD4 T cell activation and increased frequencies of cytotoxic CD4 T cells with advancing age. EBioMedicine, 2022, 82:104179.doi:10.1016/j.ebiom.2022.104179.(IF: 9.7,中科院1区).
5. Rui Li†, Thomas F. Tropea, Laurra R. Baratta, Leah Zuroff, Maria E. Diaz-Ortiz, Bo Zhang, Koji Shinoda, Ayman Rezk, Roy N. Alcalay, Alice Chen-Plotkin*, Amit Bar-Or*. Abnormal B-cell and Tfh-cell profiles in patients with Parkinson Disease: a cross-sectional study. Neurology Neuroimmunology & Neuroinflammation, 2021, 9(2): e1125. doi:10.1212/NXI.0000000000001125.(IF: 8.8,中科院1区)
6. Sokratis A. Apostolidis, Mihir Kakara, Mark M. Painter, Rishi R. Goel, Divij Mathew, Kerry Lenzi, Ayman Rezk, Kristina R. Patterson, Diego A. Espinoza, Jessy C. Kadri, Daniel M. Markowitz, Clyde E. Markowitz, Ina Mexhitaj, Dina Jacobs, Allison Babb, Michael R. Betts, Eline T. Luning Prak, Daniela Weiskopf, Alba Grifoni, Kendall A Lundgreen, Sigrid Gouma, Alessandro Sette, Paul Bates, Scott E. Hensley, Allison R. Greenplate, E. John Wherry*, Rui Li*, Amit Bar-Or*. Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy. Nature Medicine, 2021, 27(11): 1990-2001.doi:10.1038/s41591-021-01507-2.(IF: 82.9,中科院1区)
7. Amit Bar-Or†,* and Rui Li† Cellular Immunology of Multiple Sclerosis: Interactions, Checks and Balances. Lancet Neurology, 2021, 20(6): 470-483. doi:10.1016/S1474-4422(21)00063-6.(IF: 48,中科院1区)
8. Linlu Tian, Hongxue Meng, Xiao Dong, Xinlei Li, Hulun Li, Lie Zhang, Yue Yang, Ruijie Liu, Chunying Pei, Bo Li, Hongwei Xu*, Rui Li*. IRGM promotes melanoma cell survival through mediating autophagy and is a promising prognostic biomarker for clinical application. Molecular Therapy -Oncolytics, 2021, 20:187-198.doi:10.1016/j.omto.2020.12.005.(IF: 5.7,中科院2区)
9. Rui Li†, Kristina R. Patterson and Amit Bar-Or*. Reassessing B cell contributions in Multiple Sclerosis. Nature immunology, 2018, 19: 696-707.doi:10.1038/s41590-018-0135-x. (IF: 30.5,中科院1区)
10. Rui Li†, Ayman Rezk, Yusei Miyazaki, Ellen Hilgenberg, Hanane Touil, Ping Shen, Craig S. Moore, Laure Michel, Faisal Althekair, Sathy Rajasekharan, Jennifer L. Gommerman, Alexandre Prat, Simon Fillatreau, Amit Bar-Or*, Canadian B Cells in MS Team. Proinflammatory GM-CSF–producing B cells in multiple sclerosis and B cell depletion therapy. Science Translational Medicine, 2015, 7(310): 310ra166.doi:10.1126/scitranslmed.aab4176.(IF: 15.8,中科院1区)
（更新于2025年7月）
