吴则开 副研究员
硕士生导师
联系邮箱：zekaiwu@fjmu.edu.cn
个人简介
吴则开，女，副研究员，硕士生导师。于北京大学细胞生物学专业获博士学位。入选福建省高层次人才（C类）。主持福建省自然科学基金面上项目、校人才项目启动基金和福建省环境因素与肿瘤重点实验室开放课题。近五年以第一作者/通讯作者在Protein & Cell、Chemico-Biological Interactions、Frontiers in Immunology等国际主流期刊上发表论文，获批专利1项。
研究领域
1.真菌毒素的毒性评价与致消化道损伤机制研究
2.急慢性消化道疾病的致病机制与治疗
主持/参与的项目
1. 福建省自然科学基金面上项目，Kdm7aa通过组蛋白甲基化调控心脏再生的功能与机制研究，10万元，2024.11-2027.11，主持
2. 熟女a片 高层次人才启动项目，真菌毒素在肝癌发生中的功能与作用机制研究，20万元，2023.03-2028.02，主持
3. 福建省环境因素与肿瘤重点实验室开放课题，黄曲霉毒素B1诱导肝癌发生中巨噬细胞耗竭的机制研究，5万元，2025.05-2027.04，主持
4. 国家自然科学基金面上项目，蛋白磷酸酶PP6C通过调控HBx蛋白稳定性影响HBV转录与复制，48万元，2025.01-2028.12，参与
科研成果
第一作者/通讯作者：
1. Zekai Wu, Yuan Shi, Yueli Cui, Xin Xing, Liya Zhang, Da Liu, Yutian Zhang, Ji Dong, Li Jin, Meijun Pang, Rui-Ping Xiao, Zuoyan Zhu, Jing-Wei Xiong, Xiangjun Tong, Yan Zhang, Shiqiang Wang, Fuchou Tang, Bo Zhang; Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration, Protein & Cell, 2023, 14(5): 350-368（IF: 13.6，中科院1区）
2. Zekai Wu, Jian Zhang, Yajiao Wu, Mengting Chen, Hong Hu, Xinyue Gao, Chutao Li, Maodong Li, Youbo Zhang, Xiaohuang Lin, Qiaomei Yang, Li Chen, Kunqi Chen, Lifeng Zheng, An Zhu; Gelsenicine disrupted the intestinal barrier of Caenorhabditis elegans, Chemico-Biological Interactions, 2024, 395: 111036（IF: 5.4，中科院1区）
3. Xiaohuang Lin, Jian Zhang, Zekai Wu, Yuan Shi, Mengting Chen, Maodong Li, Hong Hu, Kun Tian, Xiaoqi Lv, Chutao Li, Yang Liu, Xinyue Gao, Qiaomei Yang, Kunqi Chen, An Zhu; Involvement of autophagy in mesaconitine-induced neurotoxicity in HT22 cells revealed through integrated transcriptomic, proteomic, and m6A epitranscriptomic profiling, Frontiers in Pharmacology, 2024,15: 1393717（IF: 4.8，中科院3区）
4. Yihong Zheng, Yinuo Liu, Jin Tian, Shuhong Liu, Gaowei Ma, Yupeng Xie, Chenhua Zheng, Zekai Wu; Ochratoxin A induces immunotoxicity by targeting Annexin A1 mediated neutrophil apoptosis in zebrafish, Frontiers in Immunology, 2025, 16: 1542964（IF: 5.9，中科院2区）
5. Jin Tian, Yubin Zhuang, Yinuo Liu, Yihong Zheng, Xuyang Liu, Shiyu Lin, Chenhua Zheng, Zekai Wu; ROS-mediated unfolded protein response activation drives hepatocyte apoptosis in mesaconitine-induced liver injury, Toxics, 2025, 13: 155（IF: 4.1，中科院3区）
专利：ANGPT4蛋白及其编码基因在调控心脏损伤后的修复与再生能力中的应用，第一发明人，2024.04.23，CN113956345B
参与作者：
1. Mengting Chen, Jiaxin Wen, Yiyan Qiu, Xinyue Gao, Jian Zhang, Yifan Lin, Zekai Wu, Xiaohuang Lin, An Zhu. Combining Multiple Omics with Molecular Dynamics Reveals SCP2-Mediated Cytotoxicity Effects of Aflatoxin B1 in SW480 Cells. Toxins, 2024, 16 (9): 375（IF: 4.0，中科院2区）
2. Yifan Lin, Jian Zhang, Xinyue Gao, Zekai Wu, Lele Yang, Kun Tian, Xiaoqi Lv, Jiaqi Li, Kunqi Chen, Youbo Zhang, Hong Hu, An Zhu. Toosendanin-induced liver damage through irreparable DNA damage and autophagy flow blockade. Phytomedicine. 2025;140:156586.（IF: 8.3，中科院1区）
3. Yingying Hu, Zhou Luo, Meiwen Wang, Zekai Wu, Yunxing Liu, Zhenchao Cheng, Yuhan Sun, Jing-Wei Xiong, Xiangjun Tong, Zuoyan Zhu, Bo Zhang. Prox1a promotes liver growth and differentiation by repressing cdx1b expression and intestinal fate transition in zebrafish, J Genet Genomics. 2025;52(1):66-77.（IF: 7.1，中科院1区）
（更新于2025年7月）
