卓敏 教授
博士生导师,加拿大皇家科学院院士
联系邮箱:[email protected]
个人简介
卓敏,男,加拿大籍福建裔华人,博士,教授,博士生导师,加拿大皇家科学院院士、国际知名神经科学家、多伦多大学生理系终身正教授。
研究领域
1.慢性痛和痛情绪的机制研究和新药研发
2.抗成瘾药物的机制研究和新药研发
3.脑疾病的机制研究和新药开发
主持/参与的项目
福建省高层次人才引进计划《中枢神经环路的突触可塑性机制研究》,经费1000万
科研成果(仅罗列影响因子30分以上论文)
1.Zhuo M, Small SA, Kandel ER, Hawkins RD (1993). Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus. Science 260, 1946-1950 (IF=63.714,1区)
2. Zhuo M, Hu Y, Schultz C, Kandel ER, Hawkins RD (1994). Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation. Nature 368, 635-639.(IF=69.504,1区)
3. Li P and Zhuo M (1998). Silent glutamatergic synapses and nociception in mammalian spinal cord. Nature 393, 695-698.(IF=69.504,1区)
4. Li P, Wilding TJ, Kim SJ, Calejesan AA, Huettner JE, Zhuo M (1999). Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cord. Nature 397, 161-164. (IF=69.504,1区)
5. Zhuo M and Gebhart GF (2002). Facilitation and attenuation of a visceral nociceptive reflex from the rostroventral medulla in the rat. Gastroenterology 122, 1007-1019.(IF=33.88,1区)
6. Li XY, Ko HG, Chen T, Descalzi G, Koga K, Wang H, Kim SS, Shang Y, Kwak C, Park SW, Shim J, Lee K, Collingridge GL, Kaang BK, Zhuo M (2010). Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex. Science 330:1400-1404. (Reported by Toronto Star, ABC news, Nature highlights, National Post, Science Signaling) (IF=63.714 1区)
7. Bliss TV, Collingridge GL, Kaang BK, Zhuo M (2016). Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain. Nature Neurosci. Review, 8:485-96.(IF= 38.755, 1区)
专利:
1.治疗疼痛的药物组合物,卓敏,授权时间2020.03.27,申请号KR:10-2018-0057362等。
2.5-((2-(6-氨基-9H-嘌呤-9-基)乙基)胺基)戊基-1-戊醇的结晶,卓敏,授权时间2018.05.08,申请号US:15/651,564等。
3.6-选择性抑制腺苷酸环化酶1的化合物在制备用于治疗神经性疼痛和炎性疼痛的药物中的应用,卓敏,授权时间2014.01.29,申请号JP:2008-534840等。
专著:
1.Editor: Molecular Pain. Published by Higher Education Press/Springer, 2007.
2.Chronic Pain. Min Zhuo, 2023. //www.amazon.ca/Chronic-Pain-Molecular-Insights- Treatment/dp/9814324523
(更新于2025年7月)