赵必星 副研究员
硕士生导师
联系邮箱：[email protected]
个人简介
赵必星，男，副研究员，硕士生导师。厦门大学细胞生物学专业获博士学位学位。福建省“雏鹰计划”青年拔尖人才，福建省百千万人才工程省级人选，福建省高层次人才（C类）、福建省医学会肝病学分会青年委员会副主任委员、中国抗癌协会抗癌药物专业委员会委员、中国医师协会中西医结合医师分会基础与转化医学专业委员会委员、中国医药生物技术协会科研实验室建设与管理分会委员、福建省药理学会常务理事、福建省药理学会肿瘤药理专业委员会常务委员、中华医学会肝病学分会肝病基础医学与实验诊断协作组成员、福建省医学会外科学分会实验外科及转化医学学组委员。
研究领域
主要从事肿瘤相关细胞信号转导通路、免疫治疗与精准医学方面的基础与临床转化研究
主持/参与的项目
1.国家自然科学基金面上项目（32470612），m1A甲基转移酶TRMT6通过促进eIF3a剪接成熟启动缺氧应激下的蛋白翻译重编程并促进肝细胞癌的进展，经费（50万元），起止时间（2025.1-2028.12），主持。
2.福州市卫生健康中青年人才科研项目（2024-S-rc3），工程化Dexosomes 在肝癌免疫治疗中的应用研究，经费（25万元），起止时间（2024.11-2027.10），主持。
3. 福建省科技创新联合资金项目（2021Y9032），环状RNA肿瘤新抗原疫苗在肿瘤免疫治疗中的应用研究，经费（100万），起止时间（2022.10-2025.10），主持。
4. 福建省中央引导地方科技发展资金项目（2022L3030），肝癌免疫逃逸相关lncRNA调控网络研究(福建省肝胆胰肿瘤临床医学研究中心)，经费（40万），起止时间（2022.8-2025.8），主持。
5. 福建省卫生教育联合攻关计划项目（2019-WJ-19），长链非编码RNA FAM99A在缺氧诱导的肝癌转移中的作用及机制研究，经费（20万），起止时间（2019.9-2022.9），主持。
6. 福建省卫生健康中青年骨干人才培养项目（2020GGA072），METTL16通过调控LncRNA AC079360.1 m6A甲基化促进肝癌侵袭转移，经费（10万元），起止时间（2021.1-2023.12），主持。
7. 福州市卫生健康系统科技计划创新团队培育项目（2021-S-wt2），长链非编码RNA Lnc-PLA2G4A-4通过miR-23b/Versican信号轴调控肝癌的侵袭转移，经费（8万元），起止时间（2021.9-2024.9），主持。
8. 国家自然科学基金面上项目（81672376），SALL4及其相互作用蛋白对肝癌治疗抗性的调控功能研究，经费（57万元），起止时间（2017.1-2020.2），主持。
9. 国家重点研发计划“科技助力经济2020”重点专项（SQ2020YFF0426513），病毒性肝炎相关肝癌人群预警和早筛试剂研发，经费（100万元），起止时间（2020.7-2022.6），合作主持。
科研成果
1. Yongping Lai, Fei Wang, Guang Cai, Yingying Li, Jiaxin Weng, Feifan Cai, Leijie Cai, Niangmei Cheng, Bixing Zhao, Yongyi Zeng. Utilization of Artificial Circular RNAs as miRNA Sponges and Anti-PD-1 scFv Expression Platforms to Suppress Hepatocellular Carcinoma Progression. Frontiers in Immunology. 2025. 16: 1609165.
2. Bixing Zhao, Yang Zhou, Niangmei Cheng, Xiaoyuan Zheng, Geng Chen, Xin Qi, Xiangzhi Zhang, Fei Wang, Qiuyu Zhuang, Yehuda G. Assaraf, Xiaolong Liu, Yingchao Wang, Yongyi Zeng. Targeted inhibition of PDGFRA with avapritinib, markedly enhances lenvatinib efficacy in hepatocellular carcinoma in vitro and in vivo: clinical implications. Journal of Experimental & Clinical Cancer Research. 2025. 44:139
3. Fei wang, Guang Cai, Yingchao Wang, Qiuyu Zhuang, Zhixiong Cai, Yingying Li, Shaodong Gao, Fang Li, Cuilin Zhang, Bixing Zhao, Xiaolong Liu. Circular RNA-based neoantigen vaccine for hepatocellular carcinoma immunotherapy. MedComm. 2024;5(8):e667.
4. Bixing Zhao, Xiaoyuan Zheng, Yang Wang, Niangmei Cheng, Yue Zhong, Yang Zhou, Jingyun Huang, Fei Wang, Xin Qi, Qiuyu Zhuang, Yingchao Wang, Xiaolong Liu. Lnc-CCNH-8 promotes immune escape by up-regulating PD-L1 in hepatocellular carcinoma. Molecular Therapy-Nucleic Acids, 2024. 35(1):102125
5. Peng Lyu, Fengyue Li, Runzhi Deng, Qiliang Wei, Bingkai Lin, Lei Cheng, Bixing Zhao, Zhonglei Lu. Lnc-PIK3R1, transcriptionally suppressed by YY1, inhibits hepatocellular carcinoma progression via the Lnc-PIK3R1/miR-1286/GSK3β axis. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 2024. 1870(6):167233
6. Niangmei Cheng, Xiaoyuan Zheng, Jingyun Huang, Fei Wang, Yang Wang, Yue Zhong, Yingchao Wang, Gaoxiong Wang, Bixing Zhao. TROVE2 regulated invasion and migration of hepatocellular carcinoma cells via heparanase. Oncology and Translational Medicine, 2024. 10(2):66-72
7. Yingchao Wang, Yong Yang, Ye Yang, Yuan Dang, Zhiting Guo, Qiuyu Zhuang, Xiaoyuan Zheng, Fei Wang, Niangmei Cheng, Xiaolong Liu, Wuhua Guo, Bixing Zhao. Hypoxia induces hepatocellular carcinoma metastasis via the HIF-1α/METTL16/Lnc-CSMD1-7/RBFOX2 axis. iScience, 2023. 26(12):108495
8. Yingchao Wang, Yue Zhong, Xiaoyuan Zheng, Niangmei Cheng, Yong Yang, Ye Yang, Fei Wang, Qiuyu Zhuang, Yao Huang, Wuhua Guo, Naishun Liao, Xiaoyu Yang, Bixing Zhao, Xiaolong Liu. LncRNA TIALD contributes to hepatocellular carcinoma metastasis via inducing AURKA lysosomal degradation. Cell Death Discovery. 2023; 9(1):316
9. Song You, Niangmei Cheng, Fei Wang, Xiaoyuan Zheng, Yingchao Wang, Bixing Zhao, Jingfeng Liu. Hsa_circ_0001687 Function as a ceRNA to Facilitate Hepatocellular Carcinoma Progression via miR-140-3p/FOXQ1 Axis. Protein and peptide letters, 2023, 30(11): 930-940
10. Jiahui Xiong, Yongping Lai, Niangmei Cheng, Jizhe Liu, Fei Wang, Xiaoyuan Zheng, Yingchao Wang, Qiuyu Zhuang, Yantin Lin, Jingfeng Liu, Yixuan Yang, Bixing Zhao, Xiaoyu Yang, Lnc-PLA2G4A-4 facilitates the progression of hepatocellular carcinoma by inducing versican expression via sponging miR-23b-3p. Heliyon. 2023; 9:e18698
11. Yantin Lin, Fei Wang, Yue Zhong, Niangmei Cheng, Jiahui Xiong, Xiaoyuan Zheng, Yang Zhou, Shaodong Gao, Fang Li, Yingchao Wang, Xiaoyu Yang, Bixing Zhao. Long non-coding RNA COX7C-5 promotes hepatocellular carcinoma progression via miR-581/ZEB2 axis. Cellular Signalling. 2023; 101: 110501.
12. Song You, Zijin Luo, Niangmei Cheng, Ming Wu, Yongping Lai, Fei Wang, Xiaoyuan Zheng, Yingchao Wang, Xiaolong Liu, Jingfeng Liu, Bixing Zhao. Magnetically responsive nanoplatform targeting circRNA circ_0058051 inhibits hepatocellular carcinoma progression. Drug Delivery and Translational Research. 2023;13:782-794
13. Bixing Zhao, Kun Ke, Yingchao Wang, Fei Wang, Yingjun Shi, Xiaoyuan Zheng, Xiaoyu Yang, Xiaolong Liu, Jingfeng Liu, HIF-1a and HDAC1 mediated regulation of FAM99A-miR92a signaling contributes to hypoxia induced HCC metastasis. Signal Transduction and Targeted Therapy. 2020; 5:118
14. Jizhe Liu, Fei Wang, Yindan Zhang, Jingfeng Liu, Bixing Zhao. ADAR1-Mediated RNA Editing and Its Role in Cancer. Frontiers in Cell and Developmental Biology. 2022;10:956649
15. Ying Sun, Xiaoyuan Zheng, Hui Yuan, Geng Chen, Jiahe Ouyang, Jingfeng Liu, Xiaolong Liu, Xiaohua Xing, Bixing Zhao, Proteomic Analyses Reveal Divergent Ubiquitylation Patterns in Hepatocellula Carcinoma Cell Lines With Different Metastasis Potential. Journal of proteomics. 2020;225:103834.
16. Bixing Zhao, Yingchao Wang, Xionghong Tan, Kun Ke, Cuilin Zhang, Yunzhen Gao, Naishun Liao, Yuan Dang, Yingjun Shi, Youshi Zheng, Xiaolong Liu, Jingfeng Liu, An optogenetic controllable T cell system for hepatocellular carcinoma immunotherapy. Theranostics. 2019; 9(7): 1837-1850.
17. Bixing Zhao, Yingchao Wang, Xionghong Tan, Kun Ke, Xiaoyuan Zheng, Fei Wang, Shubing Lan, Naishun Liao, Zhixiong Cai, Yingjun Shi, Youshi Zheng, Yongping Lai, Lili Wang, Qin Li, Jingfeng Liu, Aimin Huang, Xiaolong Liu. Inflammatory Micro-environment Contributes to Stemness Properties and Metastatic Potential of HCC via the NF-kappaB/miR-497/SALL4 Axis. Molecular therapy oncolytics. 2019; 15, 79-90
18. Bixing Zhao, Xiaoyuan Zheng, Xionghong Tan, Kun Ke, Fei Wang, YingchaoWang, Xiaohua Xing, Cuilin Zhang, Ping Hu, Shubing Lan, Qin Li, Aimin Huang, Xiaolong Liu. Ku80 negatively regulates the expression of OCT4 via competitive binding to SALL4 and promoting lysosomal degradation of OCT4. International Journal of Biochemistry & Cell Biology. 2020,118: 105664.
19. Xiaohua Xing, Hui Yuan, Ying Sun, Kun Ke, Xiuqing Dong, Hui Chen, Xiaolong Liu, Bixing Zhao, Aimin Huang. ANXA2Tyr23 and FLNASer2152 phosphorylation associate with poor prognosis in hepatic carcinoma revealed by quantitative phosphoproteomics analysis. Journal of proteomics. 2019, 200:111-122.
20. Hongzhi Liu, Hui Chen, Xiaomo Wu, Ying Sun, Yingchao Wang, Yongyi Zeng , Geng Chen, Xiaolong Liu, Xiaohua Xing, Bixing Zhao, Jingfeng Liu. The serum proteomics tracking of hepatocellular carcinoma early recurrence following radical resection. Cancer Management and Research. 2019;11: 2935-2946
21. Shubing Lan, Xiaoyuan Zheng, Ping Hu, Xiaohua Xing, Kun Ke, Fei Wang, Niangmei Cheng, Qiuyu Zhuang, Xiaolong Liu, Jingfeng Liu, Bixing Zhao, Yingchao Wang. Moesin facilitates metastasis of Hepatocellular carcinoma cells by improving invadopodia formation and activating β-catenin/MMP9 axis. Biochemical and Biophysical Research Communications. 2020; 524(4):861-868.
22. Youshi Zheng, Naishun Liao, Yuan Wu, Ju Gao, Zhenli Li, Wenwen Liu, Yingchao Wang, Ming Li, Xiaolou Li, Li Chen, Wenmin Zhang, Bixing Zhao, High expression of B7H2 or B7H3 is associated with poor prognosis in hepatocellular carcinoma, Molecular Medicine Reports. 2019; 19: 4315-4325.
23. Bixing Zhao, Wenxiu Zhao, Yu Wang, Yaping Xu, Jianfeng Xu, Kai Tang, Sheng Zhang, Zhenyu Yin, Qiao Wu, Xiaomin Wang, Connexin32 regulates hepatoma cell metastasis and proliferation via the p53 and Akt pathways. Oncotarget, 2015. 6(12): 10116-33.
24. Bi-xing Zhao, Hang-zi Chen, Xiao-dan Du, Jie Luo, Jian-ping He, Rong-hao Wang, Yuan Wang, Rong Wu, Ru-rong Hou, Ming Hong, Qiao Wu, Orphan receptor TR3 enhances p53 transactivation and represses DNA double-strand break repair in hepatoma cells under ionizing radiation. Molecular Endocrinology, 2011. 25(8): 1337-50.
25. Bi-xing Zhao, Hang-zi Chen, Na-zi Lei, Gui-deng Li, Wen-xiu Zhao, Yan-yan Zhan, Bo Liu, Sheng-cai Lin, Qiao Wu, p53 mediates the negative regulation of MDM2 by orphan receptor TR3. The EMBO journal, 2006. 25(24): 5703-15.
26. Xiao-Feng Lin, Bi-Xing Zhao, Hang-Zhi Chen, Xiao-Feng Ye, Chao-Yi Yang, Hai-Ying Zhou, Ming-Qing Zhang, Sheng-Cai Lin, Qiao Wu. RXRalpha acts as a carrier for TR3 nuclear export in a 9-cis retinoic acid-dependent manner in gastric cancer cells. Journal of Cell Science, 2004. 117(Pt 23):5609-21.
专利
1. 刘小龙，赵必星，刘景丰，谭雄红。一种光调控T细胞活化的表达载体、构建方法及应用。专利号：ZL 2016 1 0404536.9
2. 刘小龙，许海坡， 汤优，曾永毅，赵必星，蔡志雄，周阳。对五种输入性疟原虫分型检测的引物、探针及方法。专利号：ZL202210289664.9
荣誉与奖励
2022年 福建省科技进步一等奖，《肝癌微创与诊疗一体化技术的研究及应用》，排名第9
2022年 福建省抗癌协会科技进步奖一等奖，《肝细胞癌复发转移分子标志物筛选及机制研究》，排名第一
2022年 福州市最美科技工作者
2021年 百千万人才工程省级人选
2021年 福建省第二批“雏鹰计划”青年拔尖人才
2023年 福州市医学会医学科技突出贡献工作者
2021年 福建医学科技奖二等奖，《肝癌微创与诊疗一体化技术的研究及应用》，排名第5
2020年 第四届福州青年科技奖
2013年 福建省自然科学奖一等奖，《孤儿受体TR3通过信号转导通路抑制肿瘤细胞生长的新机制》，排名第4
2012年 厦门市科技进步一等奖，《原发性肝癌的基础与临床应用研究》，排名第8
（更新于2025年7月）
