林颖颖 副教授
硕士生导师
联系邮箱：[email protected] 、[email protected]
个人简介
林颖颖，女，副教授，硕士生导师。本科毕业于华中科技大学同济医学院，博士毕业于厦门大学生理学专业，获博士学位。在职期间，先后主持过国家自然科学基金青年基金项目、福建省卫健委青年科学基金项目和福建省自然科学基金面上项目，目前参与发表SCI论文10篇，其中以第一作者或通讯作者发表SCI论文6篇。
研究领域
1.细胞死亡与肿瘤免疫的机制研究和靶向治疗
2.感染免疫与炎症损伤的调控机制
主持/参与的项目
1.福建省科技厅自然科学基金面上项目, Quizartinib抑制TNF介导的炎症性坏死的机制研究，9万元，2023.08-2026.08，主持
2.福建省科技厅自然科学基金面上项目, TRIM34通过调控cGAS信号通路参与抗病毒免疫的机制研究，8万元，2018.04-2021.04，主持
3.国家自然科学基金青年基金项目，Jagged1-Notch信号通路调控IL-33的产生及促进乳腺癌发展的作用机制，17万元，2016.12-2020.04，主持
4.福建省卫健委青年科学基金项目，EGCG通过影响Jagged1-Notch信号通路的活化抑制乳腺癌发展和转移的作用，3万元，2016.09-2019.09，主持
5.国家自然科学基金面上项目，I型单纯疱疹病毒逃逸TRIM69介导抗病毒天然免疫的研究，55万元，2021.01-2024.12，参与
6.国家自然科学基金面上项目，中央杏仁核GABA能神经元调控睡眠-觉醒的作用和机制，48万元，2025.01-2028.12，参与
1.Danni Chen#, Yushi Chen#, Jianting Feng#, Wenyang Huang, Zeteng Han, Yuanyuan Liu, Qiaofa Lin, Lisheng Li*, Yingying Lin*. Guanine nucleotide exchange factor RABGEF1 facilitates TNFinduced necroptosis by targeting cIAP1. Biochemical and Biophysical Research Communications, 2024, 703: 149669. doi: 10.1016/j.bbrc.2024.149669.
2.Fangmin Huang#, Jiankun Liang#, Yingying Lin#, Yushi Chen, Fen Hu, Jianting Feng, Qiang Zeng, Zeteng Han, Qiaofa Lin, Yan Li, Jingyi Li, Lanqin Wu*, Lisheng Li*. Repurposing of Ibrutinib and Quizartinib as potent inhibitors of necroptosis. Communications Biology, 2023, 6(1): 972. doi: 10.1038/s42003-023-05353-5.
3.Yuan He#, Yingying Lin#, Fei He, Lijuan Shao, Wei Ma, Fei He*. Role for calcium-activated potassium channels (BK) in migration control of human hepatocellular carcinoma cells. Journal of Cellular and Molecular Medicine, 2021, 25(20): 9685-9696. doi: 10.1111/jcmm.16918.
4.Hongjuan You#, Yingying Lin#, Feng Lin, Mingyue Yang, Jiahui Li, Rongzhao Zhang, Zhiming Huang, Qingtang Shen, Renxian Tang, Chunfu Zheng*. β-Catenin is required for the cGAS/STING signaling pathway but antagonized by the herpes simplex virus 1 US3 protein. Journal of Virology, 2020, 94(5): e01847-19. doi: 10.1128/JVI.01847-19.
5.Yingying Lin, Chunfu Zheng*. A Tug of War: DNA-Sensing Antiviral Innate Immunity and Herpes Simplex Virus Type I Infection. Frontiers in microbiology, 2019, 10: 2627. doi: 10.3389/fmicb.2019.02627.
6.Lanqin Wu#, Yingying Lin#, Jinan Feng#, Yuanlin Qi#, Xinrui Wang, Qiaofa Lin, Wanyan Shi, Enrun Zheng, Wei Wang, Zhenzhu Hou, Hanbin Lin, Cheng Yu, Yan He, Yan Xu, Hong Yang, Ling Lin*, Lisheng Li*. The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein. Cancer Cell International, 2019, 19: 222. doi: 10.1186/s12935-019-0936-5.
7.Jingyi Li, Xingfeng Liu, Yuanyuan Liu, Fangmin Huang, Jiankun Liang, Yingying Lin, Fen Hu, Jianting Feng, Zeteng Han, Yushi Chen, Xuan Chen, Qiaofa Lin, Lanqin Wu*, Lisheng Li*. Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL. Cell Death & Disease, 2024, 15(2): 122. doi: 10.1038/s41419-024-06514-y.
（更新于2025年7月）
